Possible Thermogenesis with Dexfenfluramine
CHULAPORN ROONGPISUTHIPONG, M.D., ABN, F.R.C.P.T.*, ORASA PANPAKDEE, M.S.**,
ACHARA BOO NTA WEE, B.Sc. ***,
SWAIRIN KULAPONGSE, M.S.****,
VICHAI TANPHAICHITR, M.D., Ph.D, F.A.C.P, F.R.A.C.P.*
Affiliation : *Division of Nutrition and Biochemical Medicine, Department of Medicine,
**Medical Nursing Division,
*** Food and Dietetic Division,
****Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
AbstractFifty obese patients with a body mass index greater than 25 kgfm2 were randomized into
3 groups: control (C=l9), placebo (P=18) and dexfenfluramine (D=18). A behavioral modification
program which included eating habits, exercise, attitudes, social relationships and six steps to
lifetime weight control was taught every week. All patients strictly followed the food manual
and recorded their behavior, physical activity and food intake every day through 12 weeks.
Placebo and dexfenfluramine 30 mg/day were given in a double blind placebo controlled study. The
results showed tha~ all 3 groups had significant decreases in rest times and increased activity
times (p<0.05) and significant reductions of the average total daily energy, carbohydrate and fat
intake (p<0.05). They all lost weight. Mean ± SEM cumulative weight loss was 8.3±0.7 kg in
group D, 3.3±1 kg, in group P and 2.9±0.7 kg, in group C. The mean additional weight loss of 5 kg,
and 5.4 kg seen with dexfenfluramine being highly significant (p
Keywords : Thermogenesis, Possible, Dexfenfluramine
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