Estradiol and Follicle-Stimulating Hormone Levels in
Oophorectomized Women Applying Percutaneous 17
6-Estradiol Over the Medial Surface of the Left Arm
NIMIT TAECHAKRAICHANA, M.D.*,
KRASEAN PANYAKHAMLERD, M.D.*,
KOBCHITT LIMPAPHAYOM, M.D.*
SOMJAI UDOMPONGLUKKANA, M.D.*,
SMAI LEEPIPATPAIBUL*,
Affiliation : * Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkom University, Bangkok 10330, Thailand.
AbstractTo assess the changing estradiol (E2) and follicle stimulating hormone (FSH) level in
oophorectomized women applying percutaneous 17 B estradiol over the medial surface of the
left arm. Thirty-nine women, who had undergone total abdominal hysterectomy and bilateral
oophorectomy after 4 weeks, were enrolled into the study. All subjects received a daily dose
of 1.5 mg percutaneous 17 B-estradiol in 2.5 g of the gel, applied over the medial surface of the
left arm in the limited area of 150 cm2. Serum E2 and FSH were measured before and after
commencing the study at weeks 4, 8 and 12. The measurment was performed 12-14 hours after
the gel application, using time-resolved fluoroimmunoassay (FIA) method. Serum E2 sig-
nificantly increased from the baseline value at weeks 4, 8 and 12 (Median of E2 value at weeks
0, 4, 8 and 12 = 47.30, 86.78, 128.00 and 163.15 pmol/L, respectively, P<0.05). While the serum
FSH level significantly decreased. (Median of FSH value at weeks 0, 4, 8 and 12 = 66.05,
60.40, 53.35 and 48.40 IU!L, respectively, P<0.05). In conclusion, this dose, duration and route
of estrogen administration increased the serum E2 level close to the early to mid-follicular
phase of the normal menstrual cycle. While FSH level significantly decreased but did not
reach the premenopausal range.
Keywords : Estradiol, FSH, Oophorectomized Women, Percutaneous 17 B-Estradiol, Medial
Surface of Left Arm
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