Fast Liver Alkaline Phosphatase Isoenzyme in Diagnosis of Malignant Biliary Obstruction
NARA PARITPOKEE, M.Sc.*,
SUNEE TEERASAKSILP, B.Sc. *,
SOMRAT LERTMAHARIT, M.Med.Stat.***,
PISIT TANGKUVANICH, M.D.**,
VIROJ WIWANITKIT, M.D.*,
PlY ARATANA TOSUKHOWONG, M.Sc. **
Affiliation : * Department of Laboratory Medicine,
** Department of Biochemistry,
*** Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkom University, Bangkok 10330,
Thailand.
AbstractFast liver alkaline phosphatase isoenzyme was measured by cellulose acetate electro-
phoresis in the sera obtained from 84 patients with specific hepatobiliary diseases and I 0 control
subjects. The mean value of this isoenzyme in patients with malignant extrahepatic obstruction
was 130.58± 107.08 U/L, significantly higher than that of patients with benign extrahepatic
obstruction (65.63±34.14 U/L), as well as patients with intrahepatic choles~asLs and infiltra-
tive liver cancers (65.31±38.11 U/L and 48.47±36.85 U/L, respectively). Furthermore, we could
not detect this isoenzyme in normal individuals. When 100 U/L was used as a cut-off value to
discriminate between patients with malignant extrahepatic obstruction and the remaining hepato-
biliary disorders, the sensitivity, specificity and accuracy of the test were 63 per cent, 84 per cent
and 80 per cent, respectively. It is concluded that the fast liver isoenzyme could be a useful
marker in diagnosis of malignant extrahepatic obstruction.
Keywords : Alkaline Phosphatase, Isoenzymes, Jaundice, Liver Disease, Biliary Tract Disorders
All Articles
Download
