Reference Value for Urinary Deoxypyridinoline as a
Specific Marker for Measuring Bone Resorption in Thais
PHANNEE PIDETCHA, M.Sc*,
KINGKAEW PATRAKARN, M.Sc.*,
SOMSAK FONGSUPA,B.Sc.**
SRISANIT INTRAMANEE, M.Sc. *,
PAIROJ LEELAHAKUL, M.D.*,
Affiliation : * Department of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Bangkok I 0700,
** Laboratory Medicine, Thammasat Hospital, Thammasat University, Pathumthani, Thailand.
AbstractIn the next century, the increasing number of elderly and nsing healthcare costs will
bring with it metabolic bone problems, particularly osteoporosis. Deoxypyridinoline: Dpd in urine
is a sensitive and specific marker for screening and monitoring of bone resorption in a variety
of diseases affecting bone turnover and in risk groups especially in the postmenopause. The
reference value among aging (21-60 years) of a healthy well defined group was studied by col-
lecting the urine between 700-1000 hours and using the ELISA technique to determine the level
of Dpd. The reference value of Dpd in 113 males and 298 females 1.3-6.5 and 1.5-6.9 nm Dpd/nm
Creatinine respectively. The level of Dpd in females was significantly higher than in males at
p<0.028. However, the average value of deoxypyridinoline in postmenopause was higher than
premenopause but not different at p = 0.05. There are many factors which influence the results so
the overall reference value is only a guideline for screening in bone resorption.
Keywords : Deoxypyridinoline, Bone Resorption, Reference Value, Osteoporosis, Premenopause,
Postmenopause
All Articles
Download
