Efficacy of High Dose Interferon - Alpha Treatment of Chronic Hepatitis B

SATIEN TECHAPAITOON, M.D.*

Affiliation : * Department of Medicine, Rajavithi Hospital, Bangkok I 0400, Thailand. t Presented at the Alimentary Disease Week Manila, November 22-25, 1998.

AbstractFifteen consecutive Hepatitis B virus chronic hepatitis patients were treated with interferon alfa-2B 10 mu tiw for 5-6 months. All patients could tolerate the side effects without serious complications throughout the treatment period. Overall, 12 cases had normalization of ALT (80%), 7 cases had loss of HbeAg with appearance of anti-Hbe (58.33%) and 2 cases had loss of HbsAg with the presence of antiHBs (13.33%). The response usually associated with improvement in histology and decrease in viral load. These results seemed to be better than other studies with a lower dose. Further study with more patients should be done in the future.

Keywords : Chronic Hepatitis B, Interferon-Alpha, Treatment

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