Serum Insulin-like Growth Factor-1 (IGF-1) and Insulinlike Growth Factor Binding Protein-3 (IGFBP-3) in Healthy Thai Children and Adolescents: Relation to Height, Weight, and Body Mass Index
SOMCHIT JARURATANASIRIKUL, M.D.*,
HATCHA SRIPLUNG, M.D.**,
KALAYA LEETHANAPORN, M.Sc.***
Affiliation : * Department of Pediatrics,
** Department of Pathology,
*** Department of Radiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110,
Thailand.
AbstractThe objective of this study was to evaluate the correlation between serum concentrations
of insulin-like growth factor-! (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3)
and growth parameters (height, weight, and body mass index) in 260 healthy children and ado-
lescents aged 5-20 years. The subjects were divided into 2 groups according to the age achieving
final height. Group 1 included children with active growth consisting of girls aged under 14 years
(N = 80) and boys aged under 16 years (n = 74). Group 2 included adolescents who achieved final
height consisting of females aged at and over 14 years (n = 82), and males aged at and over 16
years (n = 24). In group 1, the serum concentrations of IGF-1 and IGFBP-3 were significantly
positive correlated with all growth parameters. In group 2, although the correlation was insigni-
ficant, the concentrations of IGF-1 and IGFBP-3 seemed to be greater in individuals who were
relatively taller and had lean body mass than those who were relatively short and overaverage body
mass.
Keywords : Body Mass Index (BMI), Height, Insulin-like Growth Factor-! (IGF-1), Insulin-like
Growth Factor Binding Protein-3 (IGFBP-3), Weight
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