Treatment of fsoriasis Vulgaris with Topical Vitamin D Analogue (Calcipotriol): Open Multicenter Study
PREY A KULLA V ANUA YA, M.D.*,
PORNTIP HUIPRASERT, M.D.**,
PIMONPUN GRITIYARANGSAN, M.D.*,
VICHIT LEENUTAPHONG, M.D.***
Affiliation : * Institute of Dermatology, Department of Medical Services, Ministry of Public Health, Bangkok I 0400,
** Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkom University, Bangkok 10330,
*** Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
AbstractSixty one psoriasis patients, 46 males and 15 females (mean age: 40 years, range: 20-70
years) with baseline PASI score of 7.16 (± 3.66 SD) were enrolled in the study. All subjects
were advised to apply calcipotriol ointment twice daily for 6 weeks. Six patients dropped out,
five after 2 weeks and one after 4 weeks of treatment. PASI scores of fifty five patients were
reduced to 2.16 per cent, 46.78 per cent and 55.55 per cent by 2 weeks, 4 weeks and 6 weeks res-
pectively versus the baseline. Overall clinical assessment showed remission in 7.27 per cent
marked improvement 74.54 per cent and slight improvement 18.18 per cent. Mild erythema
were observed in fourteen patients (22.95%) that were mostly transient except for one patient.
Serum creatinine, calcium and phosphate were normal throughout the study.
Keywords : Psoriasis Vulgaris, Calcipotriol, Vitamin D Analogue
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