Obesity and Risk Factors of Coronary Heart Disease in Healthy Thais : A Cross-Sectional Study
NITHI MAHANONDA, M.D.*, W A TTANA LEOWATTANA, M.D.**, CHUNHAKASEM CHOTINAIWATTARAKUL, M.D.*, MANOON SAMRANTHIN, M.D.*, KIERTUAI BHURIPANYO, M.D.*, CHARUWAN KANG KAGATE, M.S. (Biostat)*, SUWATCHAI PORNRATANARANGSI, M.D.***,
Affiliation : * Her Majesty Cardiac Center, **Department of Clinical Pathology, *** Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700. Thailand.
Association between obesity and conventional risk factors for coronary artery disease is well established. Obesity is currently c<.;'lsidered an independent risk for coronary artery disease. The relationship between body mass index (BMI) and fasting plasma lipids and glucose and blood pressures in non-obese subjects is not established. The authors studied relationships between BMI and lipids, and glucose, and blood pressure levels in healthy a population. The authors measured the weights and heights of 3,615 employees of a company during a routine yearly health examination. There were 1,250 males aged 31.3 ± 6.6 and 2,365 females aged 29.3 ± 4.9 years old. The average BMI for males and females were 23.5 ± 3.6 and 20.1 ±3.0 respectively. The levels of total cholesterol (Chol), LDL-cholesterol, and triglyceride (TG), fasting plasma glucose (FPG) had a positive relationship with BMI (r =0.22, 0.26, 0.41, 0.20; p < 0.001 ). HLD-cholesterol had a negative correlation with BMI (r = -0.36, p<0.001). Both systolic (SBP) and diastolic (DBP) blood pressures had a positive correlation with BMI. The association persisted after all values were adjusted by age and sex. BMI has a significant positive relationship with the conventional risk factors for coronary artery disease and a negative relationship with HDL-cholesterol.
Keywords : Obesity, Risk Factors, Coronary Heart Disease
