Biochemical Markers of Bone Turnover in Angio-
graphically-demonstrated Coronary Artery Disease
Patients and Healthy Thais
NARAVAT POUNGVARIN,M.D.*,
NITHI MAHANONDA, M.D.**,
SASIKANT POKUM, B.Sc. *,
WATT ANA LEOWATTANA, M.D.*,
KIERTUAI BHURIPANYO, M.D.**,
PATAMA WORAWATTANANON, B.Sc.*
Affiliation : * Department of Clinical Pathology,
** Her Majesty Cardiac Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
AbstractThe patients with coronary artery disease (CAD) were suffering from dyspnea. Physical
activity of these patients was limited. Their lifestyle may be contributory factors for osteoporosis.
Recent research has shown that biochemical markers may be used to predict future bone loss and
identify individuals at risk for osteoporosis. Our objectives were to estimate reference ranges of bone
markers in healthy Thais and to compare bone turnover between 105 healthy people and 118 CAD
patients by using biochemical markers of bone formation and resorption. Mean values of bone
markers in controls and patients were 22.9 ± 12.9, 21.6 ± 16.2 respectively for N-Mid osteocalcin
and 0.45 ± 0.30, 0.47 ± 0.37 respectively for ~-Crosslaps. There was no statistical difference of
N-Mid osteocalcin (p=0.50) and ~-Crosslaps (p=0.64) values between groups. Our data from this
study suggested that that CAD patients have no higher risk for osteoporosis than healthy
people.
Keywords : Coronary Artery Disease, Bone Marker, Osteocalcin, Crosslaps
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