Chorionic Villous Sampling: Experience of 636 Cases
Uraiwan Laksanavilai MD*, Wirawit Piyamongkol MD*,
Supatra Sirichotiyakul MD*, Fuanglada Tongprasert MD*,
Suchaya Leuwan MD*, Kasemsri Srisupundit MD*
Affiliation :
* Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University, Chiang Mai, Thailand
Objective : To describe the technical aspects and complications of chorionic villous sampling (CVS).
Material and Method: The database of CVS procedures performed between January 2004 and August 2011 at Maharaj
Nakorn Chiang Mai Hospital was assessed prospectively. Consecutive procedures during 10 to 14 gestational weeks were
included into the present study. Indications, results, and complications of the CVS were extracted and analyzed.
Results : All 636 CVS procedures were successful. Indications for CVS were fetal karyotyping, DNA analysis for severe
thalassemia disease, and for both in 36.5%, 50.6%, and 12.9%, respectively. However, 3.4% had inconclusive CVS result,
and the second trimester prenatal diagnosis procedures needed to be done. There were five cases (0.8%) of fetal loss in the
present study. Only two cases (0.3%) that fetal loss happened within two weeks of CVS procedures. Other minor complications
such as vaginal bleeding and amniotic fluid leakage were found in 0.3 to 1.3% and had no long-term effect. No case with
anomaly and procedure-related infection following the procedure was seen.
Conclusion : CVS is a safe and reliable prenatal diagnosis procedure in the first trimester. In experienced operators, fetal
loss rate was less than 1%. However, a few cases will have inconclusive CVS results and may need a confirmation during
the second trimester diagnostic procedures.
Keywords : Chorionic villous sampling, Prenatal diagnosis, Fetal loss
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