Guillain - Barre' Syndrome Following Recombinant Hepatitis B Vaccine and Literature Review

SUWANNA SINS A WAIWONG, M.D.*, PORNPEN THAMPANITCHAWONG, M.D.*

Affiliation : * Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.

AbstractA 17 year-old woman developed progressive quadriparesis with bilateral facial diplegia after immunization with recombinant hepatitis B vaccine 3 days prior. Cerebrospinal fluid analysis revealed acellular fluid with high protein level. The electrodiagnosis was compatible with demy- elinating polyneuropathy. Other potential causes of Guillain-Barre' syndrome (GBS) were ruled out. Her motor power gradually improved and returned to normal later. The temporal relationship between GBS and vaccination was suggestive of a vaccine-induced cause. Mechanisms of this very rare complication are proposed with a literature review.

Keywords : Guillain-Barre' Syndrome, Recombinant Hepatitis B Vaccine

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