Correlation Between Serum Insulin and Features of
Metabolic Syndrome in Thais
PONGAMORN BUNNAG, M.D.*,
AT ANA KONGSUKSAI, B.Sc.*,
RAJATA RAJATANAVIN,M.D.*,
SUWANNEE CHANPRASERTYOTHIN, M.Sc~ **,
BOONSONG ONGPHIPHADHANAKUL, M.D.*,
GOBCHAI PUA VILAI, M.D.*
Affiliation : • Department of Medicine,
•• Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400. Thailand.
t Supported by the Thailand Research Fund.
AbstractSeveral clinical and metabolic abnormalities, i.e. central obesity, hypertension, impaired
glucose tolerance or diabetes and dyslipidemia often cluster together and are commonly found in
patients with atherosclerotic cardiovascular disease. Hyperinsulinemia and i11_sulin resistanc~ are
often evident in subjects with these metabolic abnormalities, so called insulin resistance or
metabolic syndrome. In the present study, we looked into the correlations between serum insulin
or index of insulin sensitivity and various clinical and metabolic abnormalities. Subjects consisted
of 103 males and 118 females. Oral glucose tolerance test was performed on all subjects. Homeo-
stasis model assessment of insulin sensitivity (HOMA-S) was used to determine insulin sensitivity.
In males, HOMA-S was found to be significantly correlated with BMI, plasma glucose, insulin,
triglycerides and waist circumference. Male subjects in the highest quartile of HOMA-S also had
significantly higher systolic blood pressure compared to those in the lowest quartile. In females,
HOMA-S was significantly correlated with BMI, blood pressure, plasma glucose, insulin, tri-
glycerdies, HDL-cholesterol, waist circumferences and waist-hip ratio. However, after adjust-
ment for BMI, correlation between HOMA-S and blood pressure in women was no longer
statistically significant. We, therefore, concluded that correlations between serum insulin or index
of insulin sensitivity with certain metabolic abnormalities also existed in Thai subjects. Some of
these correlations seem to be at least in part dependent on obesity.
Keywords : Insulin Resistance, Metabolic Syndrome, Atherosclerosis, HOMA-S
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