Efficacy of UFT Plus Oral Leucovorin in Advanced Colorectal Cancer : A Multicenter Study
SUMITRA THONGPRASERT, M.D.*, SUDSA W AT LAOHA VINIJ, M.D.***, SA VITREE MAOLEEKOONPAIROJ, M.D.**, PARINYA THAVICHAIGARN, M.D.**
Affiliation : * Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200. ** Department of Medicine, Pramongkutklao Hospital, Bangkok 10300, ***Department of Medicine, Rajavithi Hospital, Bangkok 10400, Thailand.
Purpose : To evaluate the efficacy and toxicity of UFT plus oral leucovorin in advanced colorectal cancer.
Materials and Methods : Twenty cases of advanced colorectal cancer were entered into the study. All patients must have histologic proof and have measurable disease. Prior to the treat- ment all patients should have normal baseline hematology and normal liver and renal function. ECOG Performance status :::; 2 and age 18-75 years. Chemotherapeutic drugs consisted of UFT 350 mg/m"/day divided into 3 doses (8 hours apart) plus oral leucovorin 15 mg every 8 hours. Duration of treatment was 21 days per each cycle. Treatment was recycled every 28 days.
Results : Four cases (22.2%) had partial responses and six cases (33.3%) had stable disease. Duration of response was 4+-7+ months. Toxicity was darkened skin, mild diarrhea and mild alopecia.
Conclusion : UFT plus oral leucovorin was one of the active regimens in the treatment of advanced colorectal cancer.
Keywords : Advanced Colorectal Cancer, UFT, Oral Leucovorin
