Scanning Electron Microscopic Observations on
Advanced Third-Stage Larva of Gnathostoma spinigerum
After in vitro Exposure to Albendazole Sulphoxide
KOM SUKONTASON, M.D., Ph.D., D.T.M. & H.*,
KABKAEW SUKONTASON, Ph.D.*,
PIYANART KLAOLAOR, M.Sc.*,
BUDSABONG KUNTALUE, B.Sc.**,
UDOM CHAITHONG, Ph.D.*
PRAMOTE V ANITTANAKOM, Ph.D**,
Affiliation : ** Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
AbstractGnathostomiasis is the parasitic disease caused by the migration of an advanced third-stage
larva of Gnathostoma spinigerum. To date, albendazole is claimed to be the effective drug in
preventing the re2Ccurrence of migratory swelling in patients. After being exposed to I and 2
flg/ml albendazole sulphoxide (AlbSO) in vitro, the parasites moved deteriorately, however,
no dead larva was found even exposed to these concentrations for 21 consecutive days. The
topographical alterations after 21 days of albendazole sulphoxide exposure are described using a
scanning electron microscope. The marked changes in surface morphology were observed in
both neck and body regions. The tegumental surface on the neck region was swollen and covered
with fuzzy materials, whereas, the spines on the posterior region of the body were dislodged.
These changes would probably lead to reduction of intermittent cutaneous migratory swelling in
human gnathostomiasis patients.
Keywords : Scanning Electron Microscopy, Albendazole Sulphoxide, Gnathostoma spinigerum
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