Utility of Serum Cytokeratin 19 Fragment (CYFRA 21-1)
and Carcinoembryonic Antigen (CEA) as Tumour
Markers for Non-Small Cell Lung Cancer
PRANEE CHANTAPET, M.Sc.*,
PRACHAKVICH LEBNAK, M.D.*,
PRATHEEP RIANTAWAN, M.D., M.Sc.,MRCP (U.K.)**,
PANITSA GETNGERN,M.Sc.*
Affiliation : * National Institute of Health, Department of Medical Sciences, Bangkok 10400,
** Central Chest Hospital, Department of Communicable Diseases Control, Ministry of Public Health. Nonthaburi
11000, Thailand.
AbstractSerum cytokeratin 19 fragment (CYFRA 21-l) and carcinoembryonic antigen (CEA) levels
were determined with an enzyme immunoassay in 51 patients with non-small cell lung cancer
(NSCLC), 26 patients with benign lung diseases and 26 normal individuals in order to evaluate
their clinical utility in the diagnosis of NSCLC. Patients with NSCLC demonstrated higher serum
CYFRA 21-1 and CEA levels than both patients with benign lung diseases and normal group. We
used the cut off value which was derived from the 95 th percentile value of CYFRA 21-1 and CEA
levels in the group of patients with benign lung diseases; CYFRA 21-1 at 3.13 ng/ml and CEA at
7.7 ng/ml. The sensitivity and diagnostic accuracy of CYFRA 21-1 and CEA for the group of
NSCLC patients were 66.7 per cent, 76.6 per cent and 35.3 per cent, 55.8 per cent, respectively.
When combining CYFRA 21-1 with CEA, the sensitivity and diagnostic accuracy were 68.6
per cent and 66 per cent. These results suggest that CYFRA 21-1 and CEA are useful serum
markers for the diagnosis of NSCLC ; especially subtype squamous cell and adenocarcinoma, res-
pectively. The usefulness is not enhanced by combining the assay of CYFRA 21-1 and CEA.
Keywords : CYFRA 21-1, CEA, Tumour Marker, Diagnosis, Non-small Cell Lung Cancer
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