Uterine Blood Flow Response to Hormonal Replacement
Therapy in Asymptomatic Postmenopausal Women : A
Transvaginal Doppler Study
SOMCHAI TANAWATTANACHAROEN,M.D.*,
SUKANY A CHAIKITTISILPA, M.D.*,
KHUNYING KOBCHITT LIMPAPHAYOM, M.D.*
KRASEAN PANY AKHAMLERD, M.D.*,
NIMIT TAECHAKRAICHANA, M.D.*,
Affiliation : * Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok I 0330, Thailand.
AbstractTo evaluate the effect of continuous hormonal replacement therapy (HRT) on Doppler
parameters of uterine blood flow in asymptomatic postmenopausal women. Thirty-eight asymp-
tomatic postmenopausal women were recruited into the study from the outpatient menopause
clinic, Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn Uni-
versity. The study population was divided into 20 cases without any HRT (group I) and 18 cases
using continuous conjugated equine estrogen 0.625 mg/day combined with medroxyproges-
terone acetate 2.5 mg/day (group 2). The duration of HRT was 21.3 ± 9.5 (13-56) months. A
transvaginal colour flow imaging system (ALOKA SSD-2000 MultiView, Tokyo, Japan) was
used to assess uterine blood flow. Quantitative data from areas of colour were evaluated by
pulsed Doppler spectrum analysis. Resistance indices (RI) were measured as indicators of uterine
perfusion. Both groups were statistically similar with respect to age, parity, age at menopause.
height and weight. The endometrial thickness in group I and 2 were 3.8 ± 0.8 and 4.1 ± 0.6 milli-
metres, respectively. The left uterine artery Ris of group I and 2 were 0.86 ± 0.08 and 0.84 ±
0.07, respectively (p = 0.33) The right uterine artery Ris of group I and 2 were 0.87 ± 0.07 and
0.83 ± 0.06, respectively (p = 0.06). In conclusion, continuous HRT had a non-significant
influence on uterine blood flow in the postmenopausal women.
Keywords : Uterine Blood Flow, Hormonal Replacement Therapy, Transvaginal Doppler
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