Intravenous Gamma Globulin for Treatment of Chronic Idiopathic Thrombocytopenic Purpura in Children

VICHAI LAOSOMBAT, M.D., M.Sc. (Ped)*, ARANY A WIRIY ASA TEINKUL, B.Sc. *, MALAI WONGCHANCHAILERT, M.D.*

Affiliation : * Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.

AbstractA prospective and descriptive study was carried out in 17 children with chronic ITP. Five-day course of Intraglobin (400 mg/kg/d x 5) was given intravenously to 10 children with the age of 4-16 years (5 males and 5 females). Two-day course of Venoglobulin-1 (I g/kg/d x 2) was given intravenously to 7 children with the age of 3-15 years (3 males and 4 females). Intraglobin and Venoglobulin-I were effective in treating children with chronic ITP. All of the patients had transient increased in their platelet counts during the first 2 weeks. The two-day course of Veno- globulin-I was superior to the five-day course of Intraglobin. Mild adverse effects were observed in a greater percentage of patients treated by Venoglobulin-I than in patients treated by Intra- globin. Intravenous immunoglobulin was one of the choices of treatment in children with chronic ITP, but the cost of immunoglobulin or gamma globulin is quiet high.

Keywords : Immunoglobulin, Gamma Globulin, Chronic ITP, Children

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