Successful Combination Chemotherapy (Vincristine,
Procarbazine, Etoposide, and Prednisolone) in the
Treatment of Inoperable, Radioresistant Low Grade
Astrocytoma : A Case Report
MATINEE MAIPANG, M.D.*,
SUPACHAI JANJINDAMAI, M.D.*,
PUNNEE V ASIKNANONTE, M.D.*,
SIRIPORN HIRUNPAT, M.D.**
Affiliation : * Department of Pediatrics,
** Department of Radiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
AbstractA case of successful combination chemotherapy using vincnstme, procarbazine, VP-16
and prednisolone to treat an inoperable low grade astrocytoma is presented. This patient, whose
tumor was also resistant to radiotherapy, had well controlled symptoms after the initiation of chemo-
therapy. A brain CT scan demonstrated disappearance of the tumor mass after eight courses of a
combination chemotherapy regimen. She is at present symptom-free 80 months after diagnosis.
This result suggests that combination chemotherapy may offer treatment modalities for low
grade astrocytoma.
Keywords : Vincristine, Procarbazine, Etoposide, Prednisolone, Astrocytoma
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