Pharmacokinetic Studies of Cyclosporin in Thai Kidney
Transplantation Patients
THITIMA KUNGSAMRITH, M.Sc. *,
YINGYOS A VIHINGSANON, M.D.**,
SAUWALUCK CHUSIL, M.D.**,
SOMCHAI EIAM-ONG, M.D.**,
KRIANG TUNGSANGA, M.D.**,
DUANGCHIT PANOMVANANAAYUDHYA,Ph.D.*
Affiliation : * Department of Pharmacy, Faculty of Pharmaceutical Science, Chulalongkom University,
**Nephrology Unit, Department of Medicine, Faculty of Medicine, Chulalongkom University, Bangkok 10330, Thailand.
AbstractPharmacokinetic studies were performed in 10 Thai patients with kidney transplantation
who received microemulsion formulation (Neoral®) of cyclosporin A (CsA) twice daily. No agents
having pharmacokinetic effect on CsA had been used in these patients. The mean values of 12-h
AUC (area under the concentration-blood curve) were 4603.63 ± 344.61 ng•h/ml. CsA con-
centrations at 2 hours after dosing had the best value of correlation coefficient with the 12-h
AUC. Abbreviated AUC could be calculated by stepwise multiple linear regression analysis and
linear trapezoidal rule. The latter is more simple and superior to the former one.
Keywords : Neoral, 12-h AUC, Abbreviated AUC, Linear Trapezoidal Rule, Multiple Linear
Regression Analysis
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