Diabetes Mellitus in Young Thai Adults
SIRINATE KRITTIYA WONG, M.D.*,
BOONSONG ONGPHIPHADHANAKUL, M.D.*,
SUWANNEE CHANPRASERTYOTHIN, M.Sc.*, SIRIMON REUTRAKUL, M.D.*,
PONGAMORN BUNNAG, M.D.*,
RAJATA RAJATANAVIN, M.D.*,
GOBCHAI PUA VILAI, M.D.*
Affiliation : *Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
AbstractThe purposes of the present study were to I) find the prevalence of various types of
diabetes; 2) determine the prevalence of glutamate decarboxylase autoantibody (anti-GAD) and 3)
identify clinical characteristics which may help in predicting insulin deficiency in young Thai
adults with diabetes.
Subjects consisted of 93 adults with diabetes mellitus aged 15-40 years. In each subject,
basal and post glucagon C-peptide levels were determined by radioimmunoassay. Anti-GAD was
measured by radioimmunoassay and mitochondrial 3243 tRNA L
The mean age of subjects was 31.0 ± 0.7 years with age at diagnosis of 25.6 ± 0.9 years.
Thirty nine (41.9%) were males and 54 (58.1%) were females. Pancreatic calcification was found
in 7 (7.5%) of the patients while 2 (2.2%) were identified as having Wolfram syndrome. Four (4.3%)
had nonketotic diabetes with affected family members in multiple generations consistent with
MODY. Mitochondrial 3234 tRNA L gene mutation is low and as yet undefined
factors are accountable for insulin deficiency in a significant number of patients.
Keywords : Diabetes Mellitus, Autoimmunity, Glutamate Decarboxylase Antibody, Insulin Reserve,
Beta Cell Function
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