Comparison of Ofloxacin Otic Solution with Oral Amoxycillin Plus Chloramphenicol Ear Drop in Treat- ment of Chronic Suppurative Otitis Media with Acute Exacerbation

PAKPOOM SUPIYAPHUN, M.D.*, JACKRIT KORANASOPHONEPUN, M.D.*, VIRACHAI KEREKHANJANARONG, M.D.* • VEERAPONG SASTARASADHIT, M.D.*

Affiliation : * Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

AbstractThe efficacy and safety of 0.3 per cent Ofloxacin otic solution (OFLX) 6 drops twice daily was compared with those of oral Amoxycillin 500 mg three times daily plus 1 per cent Chloramphenicol ear drop at 3 drops three times daily (AMOX+CRP) in a two-week treatment of chronic suppurative otitis media (CSOM) with acute exacerbation. 80 adult patients were enrolled in a prospective, randomized, investigator-blind study at the outpatient ENT service of Chulalongkorn University Hospital.
The most common pathogens isolated at the pretreatment visit were Staphylococcus aureus (30.3%) and Pseudomonas aeruginosa (24.7%). The susceptibility of all the pathogenic isolates to ofloxacin, amoxycillin and chloramphenicol were 96.4, 57.1 and 51.8 per cent respec- tively.
The overall response expressed as an improvement or cure of otalgia, otorrhea and middle ear mucosal inflammation was recorded. It revealed that the improvement rate of the OFLX-treated patients was better than that of AMOX+CRP-treated, but was not statistically significant. However, the cure rate was significantly better in OFLX-treated than in AMOX+ CRP-treated groups in terms of painless (p=0.05) and dry (p A significant decrease in BC and SRT was revealed in OFLX-treated ears (p In conclusion, OFLX was more effective and safer than AMOX + CRP in the treatment of CSOM with acute exacerbation.

Keywords : Chronic Otitis Media, Drug Therapy, Otic Solution, Ofloxacin, Amoxycillin, Chloramphenicol

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