Antifungal Drug Combinations for Cryptococcus neoformans and Prototheca spp.

SOMBOON SRIMUANG, M.Sc.*, ANGKANA CHAIPRASERT, Dr. rer. nat.***, DEJA T ANPHAICHITRA, M.D.***** CHULARUT PRARIYACHATIGUL, Ph.D.**, WATCHARIN RUNGSIPANURATN, M.Sc.****,

Affiliation : * Research Center, Faculty of Medicine, Ramathibodi Hospital, ** Department of Microbiology, Faculty of Medical Technology, Khon Kaen University, Khon Kaen 40002, *** Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, **** Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, ** * ** Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok 10400, Thailand.

AbstractSeventy-one isolates of Cryptococcus neoformans and 5 isolates of Prototheca spp. were tested for in vitro susceptibility against amphotericin B alone and against the combination of amphotericin B with each clinically relevant concentration of flucytosine (5-FC) and rifampin by broth dilution methods. The combinations of amphotericin B and rifampin produced greater effect on reduction of the minimal inhibition concentration (MIC) of amphotericin B than did either drug used individually. Flucytosine combined with amphotericin B produced little or no reduction of the MIC compared with amphotericin B alone.

Keywords : Cryptococcus neoformans, Prototheca spp., Amphotericin B, Drug Combination

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