The Correlation of B-Subunit Human Chorionic Gonadotropin Level in the Serum and First Morning Urine
of Patients with Gestational Trophoblastic Disease
MONGKOL BENJAPIBAL, M.D.*, TUANGSIT WATAGANARA,M.D.*,
SANSANEE SENA WONG, M.D.**, DITTAKARN BORIBOONHIRUNSARN, M.D.*,
ISSARACHA SUPHANIT, B.Sc. (M.T.)*
Affiliation : * Department of Obstetrics and Gynecology,
** Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
AbstractThe purpose of this cross-sectional study was to determine the correlation of beta subunit
human chorionic gonadotropin (~-hCG) level in the serum and first morning urine samples of
patients with gestational trophoblastic disease (GTD). A total of 81 paired serum and first morning
urine samples from 24 patients diagnosed with GTD, who had their follow-up at the Division
of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj
Hospital, Mahidol University. The paired serum and first morning urine samples were measured
for ~-hCG level, using enzyme-linked immunosorbent assay (ELISA). After logarithmic transfor
mation, serum ~-hCG level was strongly and significantly correlated to those of first morning urine
samples, with the correlation coefficient of 0.97 (p < 0.01). Among the disease-remission group
(serum ~-hCG of less than 5 miU/ml), the correlation coefficient was 0.52 (p < 0.01), which was
still statistically significant. Stronger statistical significance was found in the disease-active group
(serum ~-hCG of 5 miU/ml or higher), with the correlation coefficient of 0.95 (p < 0.01). We
concluded that the level of serum ~-hCG was strongly and significantly correlated with those of
first morning urine samples, especially in patients with active disease. Determination of ~-hCG level
using first morning urine samples can be used as an effective mean in the follow-up of patients
with GTD.
Keywords : Human Chorionic Gonadotropin, Gestational Trophoblastic Disease, First Morning Urine
All Articles
Download
