Effects of Antileukotriene Among Asthmatic Patients
SAWANG SAENGHIRUNVATTANA,M.D.*
Affiliation : * Pulmonary Unit, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Objective : To determine the effect of antileukotriene (montelukast) 10 mg once daily for the treatment of mild to moderate asthma.
Design : Open label, prospective.
Patients : Thirty asthmatic patients 2: 18 years of age with baseline FEV 1 > 60 per cent and :::; 80 per cent of predicted values and evidence of reversible airway obstruction, as defined by an increase in FEY 1 of 2: 20 per cent. Interventions : Montelukast 10 mg once daily orally for 12 weeks, back up beta-2 agonist inhaler was available. Measurement and
Results : Spirometry was performed during the screening period, and every month after starting antileukotriene. Subjects recorded asthma-related symptoms and use of supplement beta-2 agonists daily on diary cards. Over 12 weeks of treatment, the FEY 1 increased I0 per cent, 14 per cent and 19 per cent respectively, compared to the baseline (p < 0.05). The physician and patients evaluation scores were quite good in the study.
Conclusion : Oral montelukast once daily gave a favorable effect in management of mild to moderate asthmatic patients.
Keywords : Asthma, Antileukotriene
