Amniotic Membrane Transplantation for Ocular Sur face Reconstructiont
PINNITA PRABHASA W AT, M.D.*,***, PANIDA KOSRIRUKVONGS, M.D.*,***, WIPAW EE BOORANAPONG, M.D.*, YONGYUTRA VAJARADUL,M.D.**,***
Affiliation : * Department of Ophthalmology, ** Department of Orthopedics Surgery, *** The Bangkok Biomaterial Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. t Supported in part by the grant of Faculty of Medicine Siriraj Hospital, Mahidol University Presented in part at the Seventh International Conference on Tissue Bank Asia Pacific Association of Surgical Tissue Banks, Kuala Lumpur, Malaysia, November 1998, in part at the Thai-Japan Joint meeting, Bangkok, Thailand, January 1999 and in part at the Fourth Annual Meeting of the Ocular Surface and Tear Conference, Miami, Aorida, USA May 1999.
Objective : To study the efficacy of amniotic membrane transplantation in various indica tions for ocular surface reconstruction.
Method : Amniotic membrane transplantations were performed in 140 eyes (130 patients) for ocular surface reconstruction. The indications for the corneal group were limbal stem cell defi ciency, bullous keratopathy, persistent epithelial defect, band keratopathy, prosthesis, corneal ulcer and acute chemical burn. The indications for the conjunctival group were grafts for pterygium, conjunctival tumors, symblepharon, and covering the scleral graft.
Results : Success was noted in 75.7 per cent (106/140) eyes, partial success in 17.9 per cent (251140) eyes, and failure in 6.4 per cent (9/140) eyes for a mean follow-up of 6.6 months (1-19 months). The success and partial success rate were 80.6 per cent (54/67), 14.9 per cent (10/67) in the corneal group and 71.2 per cent (52173), 20.6 per cent (15173) in the conjunctival group.
Conclusion : Amniotic membrane transplantation can solve some difficult ocular surface problems, and can be used to promote epithelial healing, reduce inflammation and scarring.
Keywords : Amniotic Membrane, Amniotic Membrane Transplantation, Corneal Surface recon struction, Conjunctival Surface Reconstruction, Limbal Stem Cell Deficiency, Persis tent Epithelial Defect, Conjunctival Tumor, Pterygium, Symblepharon
