Midazolam for the Treatment of Phantom Limb Pain Exacerbation : Preliminary Reportst

CHOMCHAI VICHITRANANDA, M.D.*, SOMSRI PAUSAWASDI,M.D.*

Affiliation : * Department of Anesthesiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. t Presented at the 9m World Congress on Pain, August 24, 1999, Vienna, Austria.

AbstractPhantom pain is one of the most difficult intractable pains to manage. The pain may result from the imbalance of self-sustaining neural activity that exceeds the inhibitory control. The management of acute severe exacerbation of phantom pain is extremely difficult. Midazolam acts by potentiation of gamma aminobutyric acid (GABA) and enhance the inhibitory action of glycine receptor at spinal neurons. We describe two preliminary reports of complete pain relief of severe phantom pain exacerbation by intravenous midazolam 3-5 mg.

Keywords : Phantom Pain, Midazolam

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