Effectiveness of Clopidogrel and Aspirin Versus Ticlo- pidine and Aspirin After Coronary Stent Implantation: 1 and 6-month Follow-Up
CHUMPOL PIAMSOMBOON, M.D.*, BOONSERT CHATLAONG, M.D.*, CHANARONG NASA WADI, M.D.*, MEYTHEE LEELAPRUTE, M.D.*, NANTAKA AMORNSAK, B.Sn. PRASART LAOTHA VORN,M.D. *, SOPON SAGUANWONG, M.D.*, PRAVIT TANPRASERT, M.D.*, UNCHALEE INTAYAKORN, B.Sc.*,
Affiliation : * Cardiovascular Division, Department of Medicine, Phramongkutklao College of Medicine, Bangkok I 0400, Thailand.
Background : Clopidogrel is a new thienopyridine derivative and has less serious hemato-
logic complications. We investigated the efficacy of clopidogrel plus aspirin (CA) in stent throm-
bosis prevention compared with ticlopidine plus aspirin (TA).
Method and
Results : Sixty-eight patients who underwent coronary stenting were ran-
domized into 2 groups: TA group, n = 31 and CA group, n = 37. At 1 month, there were 3 major
bleeding complications, 2 in the CA group and 1 in the TA group. Neither stent thrombosis nor
hematologic events were found in both groups. Two patients in the T A group died, 1 from sudden
death and another from tracheal stenosis. At 6 months, five patients developed in-stent restenosis,
4 in the CA group and 1 in the TA group, p = NS. One patient in each group had acute coronary
syndrome.
Conclusion : Clopidogrel plus aspirin is an effective coronary stenting regimen compa-
rable to ticlopidine plus aspirin.
Keywords : Clopidogrel, Coronary, Stent
