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Presumably Entomophthoramycosis in an HIV-Infected Patient : The First in Thailand

VIBOON BOONSARNGSUK, M.D.*, CHUSANA SUANKRATAY, M.D, Ph.D.*, HENRY WILDE, M.D.**

Affiliation : * Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkom University, ** Queen Saovabha Memorial Institute, Bangkok 10330, Thailand.

Abstract
The authors reported the case of a symptomatic HIV-infected woman with a slowly progres- sive infiltrative lesion which invaded in and around the nasal cavity over a 6-month period. Physi- cal examination showed erythematous to violaceous plaques at the nasal and malar areas. Swelling of the inferior turbinate was noted in the right nare. Skin biopsy of the involved area revealed multiple nonseptate, broad, thin-walled hyphae within giant cells and granulomata. Entomophthora- mycosis was diagnosed based on clinical features and histopathology. She was treated with intra- venous amphotericin B for two weeks, followed by oral itraconazole 400 mg daily. At six months there was complete resolution of all lesions.

Keywords : Entomophthoramycosis, Conidiobolus, Entomophthorales, HIV


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