Prevention of HIV Transmission from Mother-to-Child
in Srinagarind Hospital
CHUANCHOM SAKONDHA VAT, M.D.*,
POPE KOSALARAKSA, M.D.*,
JADSADA THINKHAMROP, M.D.*,
JAMRAS WONGKHAM, B.Sc*,
PIANGJIT THAMPRISAN, B.Sc*,
LUGSANA LUEPRASERT, M.Sc.***
PAKAPHAN KIATCHOOSKUL, M.D.*,
SIRIPORN INTARAKAMHAENG, M.Sc.**,
PATTAMA V ADEE PINITSOONTORN, B.Sc. *,
PORNPEN PA TOOMVIV AT ANA, B.Sc*,
PUANGRATNA CHAOV ARATNA, M.Sc. *,
Affiliation : * Faculty of Medicine,
**Faculty of Nursing, Khon Kaen University, Khon Kaen 40002,
*** Medical Science Center, Khon Kaen 40000, Thailand.
AbstractFrom January 1996 to December 1999, HIV infected pregnant women and their newborns
were studied. Informed consent was obtained and HIV -tests were performed after counselling. ZDV
for perinatal prophylaxis starting on week 14 to week 36 of gestation and continued throughout
pregnancy was given following an ACTO 076 regimen except that during labour, intravenous ZDV
was replaced by oral ZDV 300 mgs, given every 3-hours as a loading dose and ZDV syrup 2
mgs/kg every 6 hours for 7 days orally for the newborns. Newborn HIV-Ab and PCR were done
at 6 weeks and 6 months after birth. Eighty-four HIV infected pregnant women were enrolled in
the study, eighty-three of whom were delivered. The overall transmission rate was 5.2 per cent,
with 3/58 children confirmed infected with HIV by at least two positive PCR test results.
Keywords : HIV, Perinatal Transmission, ZDV (Zidovudine)
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