Effect of Bifidobacterium Bb12 with or without Strepto
coccus thermophilus Supplemented Formula on Nutri
tional Status
SUPUJCHARA NOPCHINDA, D.Sc.*, WANDEE V ARA VITHYA, M.D.**,
PORNPIMOL PHUAPRADIT, M.D.**, RAWIWAN SANGCHAI, M.P.H.***,
****,
UMAPORN SUTHUTVORA VUT, M.D.**, VINITA CHANTRARUKSA, B.H.E.
FERDINAND HASCHKE, M.D.*****
Affiliation : * Research Center,
** Department of Pediatrics, Faculty of Medicine,
*** Faculty of Public Health,
**** Division of Food and Nutrition, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400,
Thailand.
***** Nestle Research Center, Lausanne, Switzerland.
AbstractAcute diarrhea is a common cause of infant morbidity and mortality. Probiotic supple
mented infant formula is one of the effective methods for prevention of rotavirus diarrhea. Other
benefits of the probiotics supplemented formula were evaluated by monitoring the growth of the
children. A double-blind, placebo-controlled trial was done in 148 children aged 6-36 months. They
were divided into 3 groups: the Bb12 group, 51 children received infant formula with Bifidobacteria
Bb12 supplement; the Bbl2+ST group, 54 children received infant formula with Bbl2 and Strepto
coccus thermophilus supplement; and the control group, 43 children received infant formula without
supplement. The mean weight Z-score according to WHO reference standard of the Bb12 group was
-1.8 ± 0.12, the Bb12+ST group was -1.4 ± 0.11 and the control group was -1.8 ± 0.13 at entry. The
mean weight Z-score of children after 6 month showed that the children in the Bb12+ST group had
the highest increase in weight which was increased from -1.4 ± 0.11 to -0.9 ± 0.12 compared to the
Z-score of the Bb12 group which had increased from -1.8 ± 0.12 to -1.2 ± 0.13 and in the control
group from -1.8 ± 0.13 to -1.7 ± 0.25. In terms of the mean height Z-score, the Bb12 group was -2.7 ±
0.14 to -1.7 ± 0.16 which was higher than the Bb12+ST group(- 2.2 ± 0.13 to -1.7 ± 0.13) but was
not different from the control group. However, the mean weight/height Z-score of the Bb12+ST
group had approached the reference standard (Bb 12 group -0.1 ± 0.11 to -0.1 ± 0.13, Bb 12+ST
group -0.1 ± 0.10 to 0.3 ± 0.17, control group -0.4 ± 0.12 to -0.1 ± 0.16). Data showed that children
who received the probiotics supplement formula had better growth during the 6 month period.
Keywords : Bifidobacterium Bbl2, Streptococcus thermophilus, Probiotic
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