Respiratory Syncytial Virus-Associated Lower Respira
tory Tract Infection in Under-5-Year-Old Children in a
Rural Community of Central Thailand, a Population
Based Study
SUBHAREE SUWANJUTHA, M.D.*, PRAMUAN SUNAKORN, M.D.**,
TEERACHAI CHANTAROJANASIRI, M.D.*, SONTANA SIRITANTIKORN, M.Sc., Dr.rer.nat.***,
SUNTI NAWANOPARATKUL, M.D.****, TAPANOK RATTANADILOK NA BHUKET,M.D.**,
PRA TUENG TEEY APAIBOONSILPA, M.D.****, AROONWAN PREUTTHIPAN, M.D.*,
WA TCHAREE SAREEBUTR, M.Sc. **, PILAIPAN PUTHA VA THANA, Ph.D.***
Affiliation : * Division of Pediatric Pulmonary Disease, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital,
Mahidol University, Bangkok 10400,
** ARI Section, Department of Communicable Disease Control, Ministry of Public Health, Bangkok 10120,
*** Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700,
**** Takhli District Hospital, Nakhon Sawan Provincial Health Office, Nakhon Sawan 60000, Thailand.
AbstractThe population-based cohort study on the epidemiology of respiratory syncytial virus (RSV)
associated lower respiratory tract infection (LRI) (RSV-LRI) was conducted in Takhli district from
November 1998 to February 2001. The incidence of RSV-LRI was 12.6/1,000 child-year and 5.8/
1,000 child-year during the first and second year, respectively. RSV accounted for 35.8 per cent of
all LRI cases during the first year and significantly decreased to 17.5 per cent during the second
year. Three-quarters of RSV -LRI occurred among children under 2 years old (76.6% during the first
year and 62.2% during the second year). Most of RSV -LRI in both years occurred from July to October.
=
Risk factor for morbidity of RSV infections were age less than or equal to 2 years (OR 2.38,
95% CI = 1.22-4.67 p = 0.009) and sleeping with more than 3 persons in the patient's bedroom (OR=
2.92, 95% CI = 1.42-6.00, p = 0.002). Most RSV-LRI (63.9%) were clinically diagnosed as having
pneumonia. No RSV -LRI deaths were detected. During the first year, RSV subtype B was predo
minate, in contrast to the second year when subtype A was more predominate. Further research to
determine the annual change in subtype of RSV-LRI and correlation of severity of disease with specific
subtypes needs to conducted in order to prepare for the future introduction of a vaccine.
Keywords : Respiratory Syncytial Virus, Lower Respiratory Tract Infection
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