Can Lidocaine Reduce Succinylcholine Induced Post operative Myalgia?

SOMCHAI AMORNYOTIN, M.D.*, UBOLRAT SANTAWAT,M.D.*, PRANEE RACHATAMUKAYANANT,M.D.*, PASSAPORN NILSUWANKOSIT, M.D.*, HATAIRAT PIPATNARAPHONG, M.D.*

Affiliation : *Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

AbstractThis study was undertaken to determine the effect of lidocaine pretreatment on reduction of succinylcholine-induced myalgia in patients undergoing general anesthesia for gynecological surgery. One hundred and thirty-five patients were assigned to one of three groups in a prospective, double blind, randomized manner. Group PS, the control group, received normal saline and succinyl choline 1.5 mg.kg-1 Group LS, lidocaine 1.5 mg.kg-1 and succinylcholine 1.5 mg.kg-1 Group PR, ; ; normal saline and rocuronium 0.6 mg.kg-1 * Morphine 0.1 mg.kg-1 iv was given for premedication and all patients were monitored with a noninvasive blood pressure monitor, ECG and pulse oximetry. Anesthesia was induced with 5 mg.kg-1 thiopental iv. followed by succinylcholine (Group PS, LS) or rocuronium (Group PR) for tracheal intubation. Following administration of these agents, the presence, and degree of fasciculation were assessed visually on a four point scale by one investigator who was blinded to the drug administered. The blood pressure and heart rate of each patient were monitored on nine occasions. Twenty-four hours later, any myalgia experienced was assessed accord ing to a structured questionaire and graded by a four point scale by one investigator blinded to the intraoperative management. The results indicate that muscle fasciculation was not found in Group PR while the patients in Group LS had a lower incidence of muscle fasciculation than those in Group PS (p

Keywords : Lidocaine, Succinylcholine, Postoperative Myalgia

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