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Mental State Change after General and Regional Anes thesia in Adults and Elderly Patients, a Randomized Cli nical Trial

PRADIT SOMPRAKIT, M.D.*, JARIYA LERTAKYAMANEE, M.D.*, CHALERMKIAT SATTARAT ANAMAI, M.D.*, SIWAPORN WANICKSAMBAN, M.D.*, AURASA SILAPADECH, B.N.*, PHETCHAREE CHAINCHOP, B.N. *, VEE MUANGSUAY,M.D.*

Affiliation : *Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Abstract
Background : Mental state changes after anesthesia seemed to be more frequent in older patients, but the results were still unclear.
Objective : To compare the mental scores between adults and elderly patients after general and regional anesthesia. Methods : This was a stratified randomized trial with factorial design. Sixty patients~ 60 years old and sixty patients < 60 years old were randomly assigned to receive general or regional anesthesia. Their mental states were assessed blind by investigators, using the Thai Mental State Examination score.
Results : The two anesthetic groups showed no difference in the mental scores, but the two age groups showed significantly different scores. The components of mental states that were signifi cantly different were orientation and recall. There were no significant differences in registration, attention, calculation and language. The model for predicting the score included age, education level and narcotics given within six hours before assessment. Sex, weight, intraoperative hypotension, blood loss and duration of anesthesia could not explain the change in the scores.
Conclusion : Age, but not anesthetic technique, affected the mental scores after anesthesia.

Keywords : Anesthetic Technique, General Anesthesia, Regional Anesthesia, Mental State Change in Adults and Elderly Patients


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