Serum Sickness and Hepatitis B Vaccine Including Review of the Literaturet

THASCHA WEE ARKACHAISRI, M.D.*

Affiliation : * Division of Pediatric Rheumatology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol Univer sity, Bangkok 10700, Thailand. t Part of this manuscript was presented at the 1997 American College of Allergy, Asthma and Immunology Annual Meeting in San Diego, CA.

AbstractHB vaccine is one of the most widely administered vaccines in the world. Its efficacy approaches 95 per cent. The majority of adverse reactions are generally mild, although there have been individual case reports of serious reactions since the vaccine has become commercially avai lable. Here, a patient with a serum sickness-like reaction after her second HB immunization is reported. Review of the literature for reports of serious adverse reactions to the vaccine was also carried out.

Keywords : Hepatitis B Vaccine, Serum Sickness, Adverse Reactions

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