Kikuchi-Fujimoto's Disease, Histiocytic Necrotizing Lym phadenitis, Mimicking Systemic Lupus Erythematosus

PIROON MOOTSIKAPUN, M.D.*, JITTIMA SIRUERACHAI, M.D.*, RATANAVADEE NANAGARA, M.D.*

Affiliation : *Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

AbstractKikuchi-Fujimoto's disease (KFD) or histiocytic necrotizing lymphadenitis is a self-limit ing condition characterized by fever, neutropenia and lymphadenopathy. It is rarely associated with systemic lupus erythematosus (SLE). The authors reported a case of Kikuchi's necrotizing lympha denitis who presented with fever, generalized lymphadenopathy, moderate leukopenia, polyarthritis, vasculitis-like lesions and oral ulcers compatible with SLE but serologic tests for autoimmune disease were all negative. The clinical symptoms resolved spontaneously within 3 months without any treat ment. Because there is an association between KFD and SLE, great care should be taken with a patient who presents with either KFD or SLE.

Keywords : Kikuchi-Fujimoto's Disease, Histiocytic Necrotizing Lymphadenitis, Systemic Lupus Erythematosus

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