Influence of Normal Ageing on Mechanism of Bone Loss
in Women and Men in Bangkok
LA-OR CHAILURKIT, Ph.D.*,
NOPPA WAN PIASEU, B.Sc., M.Sc. *,
RAJATA RAJATANAVIN,M.D.*
Affiliation : *Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
AbstractAge and sex related changes in bone metabolism are of interest in the pathogenesis of
osteoporosis. However, most data in the literature were studied in Western countries. In a tropical
country, such as Thailand, little is known of vitamin D status and bone remodeling. Thus, the aim
of this study was to determine the changes of vitamin D levels and biochemical markers of bone
turnover in healthy women and men of various age groups between 20-80 years who were living in
Bangkok. From the results, vitamin D levels of various age groups did not alter significantly between
men and women except in the sixth decade of women. However, men had higher levels of vitamin
D than women. In women, all biochemical markers of bone turnover increased with age, with a
sharp increase at the onset of menopause. In contrast, biochemical markers of bone turnover in men
gradually declined with advancing age.
Conclusion : There was no evidence of vitamin D deficiency in the Bangkok population.
Women and men showed different age-related changes in bone metabolism.
Keywords : Vitamin D, Bone Markers, Bone Loss
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