Comparative Study of the Efficacy of Topical Cortico steroid : Five Locally Made and One Brand Name Creamst
SIRIPEN PUA VILAI, M.D.*, NOPADON NOPPAKUN, M.D.**, PANWIPA KRISADAPHONG, Ph.D.***, SOMYOT CHARUWICHITRATANA, M.D.*, VICHIT LEENUTAPHONG, M.D.****, KANOKVALAI KULTHANAN, M.D.****, PRA VIT ASA WANONDA, M.D.**, PORNTIP HUIPRASERT, M.D.**, RUTSANEE AKARAPHAN, M.D.*****, POOHGLIN TRESUKOSOL, M.D.*****, TANUSIN PLOYSANGHAM, M.D.******, SUWIRAKORN OPHASWONGSE, M.D.*******, SUWANNA RUANGKARNCHANASETR, M.D.********
Affiliation : * Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ** Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkom University, Bangkok 10330, *** Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ,'," **** Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ***** Institute of Dermatology, Department of Medical Services, Ministry of Public Health, Bangkok 10400, ****** Biophile Corporation Ltd., Bangkok 10330, -******* Division of Dermatology, Department of Medicine, Faculty of Medicine, Srinakarinviroj University, Nakhon Nayok 26120, ******** Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. t Presented at the annual meeting of Dermatological Society of Thailand, Bangkok, March 15-16, 2001 and the annual meeting of the Royal Colleage of Physicians of Thailand, April 26, 2001. t Grant supported by National Research Council of Thailand and Dermatological Society of Thailand.
The study was divided into 3 parts 1) pharmacological study, 2) vasoconstriction test, and 3) double blind clinical trial.
The results showed that the pharmacological properties of the locally made products were not different from the brand name product. Product C and D could diffuse through cellulose acetate membrane 3 fold more than the brand name product. Product D and E caused less vasoconstriction than the brand name product. This double blind study showed that all locally made products could improve psoriasis to the same extent as the brand name product, but there was more recurrence of psoriasis while using all the locally made products.
It was concluded that locally made products were as effective as the brand name product in the treatment of psoriasis evaluated over a 2 week peroid, but more recurrence was observed with locally made products.
Keywords : Topical Steroid, Locally Made, Brand Name, Clobetasol Propionate
