A Comparative Study of the Side Effects Between Pseu
:doephedrine in Loratadine Plus Pseudoephedrine Sul
fate Repetabs Tablest and Loratadine + Pseudoephedrine
Tablet in Treatment of Allergic Rhinitis in Thai Patients
PAKPOOM SUPIYAPHUN, M.D.*, LADDA CHOCHAIPANICHNON, M.D.*,
VIRACHAI KEREKHANJANARONG, M.D.*, SUPINDA SAENGPANICH, M.D.*
Affiliation : *Department of Otolaryngology, Faculty of Medicine, Chulalongkom University, Bangkok 10330, Thailand.
t Loratadine plus Pseudoephedrine Sulfate Repetabs Tables = Clarinase Repetab® (Schering-Piough Ltd.)
AbstractThe objective of the study was to evaluate the adverse reactions of Loratadine plus
Pseudoephedrine Sulfate Repetabs Tables (LTD+PSE Repetabs) (Loratadine 5 mg +Pseudoephedrine
120 mg) twice daily with that of loratadine (5 mg) twice daily and pseudoephedrine (60 mg) quarter
daily in the treatment of patients with allergic rhinitis. The study was designed as an investigator
blind, parallel group study. In this study, 56 patients were equally separated into 2 groups and treated
for 14 days with either L TD+PSE Repetabs or loratadine + pseudoephedrine tablet. Both groups were
comparable in age, gender, weight; baseline systolic blood pressure, diastolic blood pressure and pulse
rate. The change of systolic blood pressure, diastolic blood pressure, and pulse rate did not reach cli
nical significance throughout the study period. There was no significant difference in occurrences of
insomnia, palpitation, mouth dryness and anxiety. However, the incidence of patients with tremor at
day 14 in the loratadine +pseudoephedrine tablet group was significantly higher than the LTD+PSE
=
Repetabs group (39% vs 10.7%, p-value 0.03). Furthermore, one patient in the loratadine +
pseudoephedrine tablet group had to discontinue medication at day 7 due to insomnia. In conclusion,
LT D+PSE Repetabs is well tolerated and has fewer adverse effects when compared to the lorata
dine + pseudoephedrine tablet.
Keywords : Pseudoephedrine, Loratadine, Drug Side Effects, Allergic Rhinitis
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