Hb G Makassar (Beta 6 : Glu->Ala) in a Thai Family
SIRIPAKORN SANGKITPORN, M.Sc.*, CHARTCHAI MITRAKUL, M.D.**,
BUDSABA RERKAMNUAYCHOKE, D.M.Sc. ***, YAVAMAL SUTIVIGIT, B.Sc.****,
SOMCHAI SANGKITPORN, M.D.*
Affiliation : * National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000,
** Songkhla Hospital, Songkhla 90100,
*** Depwtmcnt of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400,
**** Regional Medical Sciences Center, Songkhla 90100, Thailand.
AbstractHemoglobin G Makassar was identified in a family of Thai origin, which was found to
share identical properties with hemoglobin S in routine hemoglobin separation both by cellulose
acetate electrophoresis and cation-exchange HPLC. It is, therefore, subjects with hemoglobin G
Makassar and hemoglobin S who may sometimes be mistakenly identified for each other. In this
study, identification of hemoglobin G Makassar was achieved by DNA sequence analysis, which
revealed a single nucleotide substitution GAG~GCG at codon 6 of the beta-globin gene. The
hemoglobin variant was hemoglobin G Makassar [beta 6 : Glu~Ala]. This is the first report of
hemoglobin G Makassar in Thailand.
Keywords : Hemoglobin G Makassar, Thailand
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