A Placebo-Controlled, Randomized Trial of Droperidol
versus Metoclopramide for Outpatients Undergoing
Gynecological Laparoscopy under Conscious Sedation
KETCHADA UERPAIROJKIT, M.D.*,
BUSARALUK PA VA VES, M.D.*,
JONGLUK NALAWACHAI, M.D.*
Affiliation : * Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University, bangkok 10330, Thailand.
AbstractThis study compared the prophylactic antiemetic efficacy and the adverse effects of
0.5 mg droperidol, 5.0 mg metoclopramide, and placebo for outpatients undergoing gynecological
laparoscopy under conscious sedation. One hundred and fifty outpatients were randomly allocated,
in a randomized double-blind manner, into three groups to receive intravenous normal saline, 0.5
mg droperidol, and 5.0 mg metoclopramide before operation. Conscious sedation using intravenous
pethidine, midazolam and local infiltration were given to each patient during the operation. Emetic
symptoms were graded twice by the patients, at discharge time and the 24'h post-operative hour.
The difference of antiemetic effect of both study drugs failed to reach statistical signifi
cance. There was also no statistical difference of intra-operative hypoxemia, sedation score, and
discharge time among the groups. Therefore, using 0.5 mg droperidol or 5.0 mg metoclopramide is
not effective in providing antiemetic prophylaxis for outpatients undergoing gynecological laparo
scopy under conscious sedation.
Keywords : Droperidol, Metoclopramide, Laparoscopy, Gynecologic, Sedation
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