Association Between Estrogen Receptor Concentration
n Breast Cancer Tissue and Bone Mineral Density
SUTIN SRIUSSADAPORN, M.D.*, VI CHIEN SRIMUNINNIMIT, M.D.*,
SIRIRAT PLOYBUTR, M.Sc. *, MONCHAYA TANLAKIT,B.PH.*,
SUPORNPIM CHEARSKUL, M.D.** * SURACHAT CHAKRAPEE-SIRISUK, M.D.*,
WANNEE NITIYANANT, M.D.*, SA THIT V ANNASAENG, M.D.*,
PAIROJ SINLARAT, M.D.*, APICHATI VICHAYANRAT, M.D.*
Affiliation : * Department of Medicine,
** Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
AbstractBoth bone and the breast are major target tissues of estrogen actions. The biological actions
of estrogen depend on the interaction between estrogen and estrogen receptors (ER) in the target
tissues. Therefore, ER concentration in tissues such as breast cancer might be associated with the
amount of bone mass. The present study was aimed to examine whether there is a relationship be
tween ER concentration in breast cancer tissue (ER-BCA) and bone mineral density (BMD). Forty
seven pre-menopausal and 34 post-menopausal women with newly diagnosed breast cancer were
studied. The ER-BCA ranged from 0 to 339 fmol/mg cytosol protein (mean ± SD = 68.6 ± 97.0).
Pearson's correlation analyses showed that ER-BCA negatively correlated to BMD of the spine
(r = -0.251, p = 0.024), forearm (r = -0.341, p = 0.002), hip (r = -0.373, p = 0.001) and total body
= =
(r -0.317, p 0.004) in all 81 women. In 47 pre-menopausal women, the ER-BCA negatively
correlated to the hip (r = -0.455, p = 0.001) and total body (r = -0.395, p = 0.006) but not to the
spine and forearm BMD. Whereas, in 34 post-menopausal women, the ER-BCA negatively cor
=
related to forearm BMD (r = -0.399, p 0.019). Stepwise multiple regression analyses showed that
=
the ER-BCA independently correlated to hip BMD in all 81 women (r -0.373, p < 0.0 I) and in
=
pre-menopausal women (r -0.486, p < 0.001) and independently correlated to forearm BMD in
=
post-menopausal women (r -0.399, p < 0.05). The results of this study suggest that the presence
of high estrogen receptor concentration in breast cancer tissue might induce a deleterious effect on
bone mass particularly in pre-menopausal women.
Keywords : Breast Cancer, Bone Mineral Density, Estrogen Receptor Concentration, Pre-Meno
pause, Post-Menopause
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