Drug Eruptions : The Value of Oral Rechallenge Test
and Patch Testt
SIRIPEN PUAVILAI, M.D.*, SOMNUK KAMTA VEE, M.D.*,
AMORNSRI CHUNHARAS, M.D.*, SUKANLAYA PONGWIRIYAPANICH, M.D.**
Affiliation : * Division of Dermatology, Department of Medicine,
** Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
t Presented at the Annual Meeting of Dermatological Society of Thailand, Bangkok, March 4-5, 1999.
AbstractAll in-and out-patients, who came for drug eruption consultation at the Dermatology Clinic,
Ramathibodi Hospital from December 1997 to November 1998 were included in this study. Medical
histories and physical examinations were performed by one of the authors. In suspected cases, a
skin biopsy was performed to confirm the diagnosis. Patch test and oral challenge test were per
formed in some patients who had maculopapular, fixed drug eruption and acute generalized exan
thematous pustulosis, with informed consent.
Among 80 patients, the most common cutaneous reaction was maculopapular rash. Anti
microbial drugs were the most common causative agents. The patch test was positive in only one
patient from 12 cases. The oral provocative test was positive in two patients from 4 cases.
It is concluded that oral provocative test is still necessary to get a definite diagnosis of
causative agent. The value of patch test needs further study.
Keywords : Drug Eruption, Oral Challenge Test, Patch Test
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