Blood Pressure Response to Antihypertensive Agents
Related to Baseline Blood Pressure
ANAWAT SERMSWAN, M.D.*, YINGNOI UBOLDEJPRACHARAK, M.D.**,
TAVORN SUTHICHAIYAKUL, M.D.***, APICHART SUKONTASARN, M.D.****,
PEERA BURANAKITCHAROEN, M.D.*****
Affiliation : * Cardiovascular Unit, Department of Medicine, Bangkok Metropolitan Administration Medical College and Vajira
Hospital, Bangkok 10300,
**Department of Medicine, Pramongkutklao Hospital, Bangkok 10400
*** Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330,
**** Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200,
***** Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
AbstractPrevalence of white-coat hypertension varies approximately 20 per cent among mild hyper
tensives. When white-coat hypertensives are prescribed antihypertensive medication, there is usually
a decrease in clinic blood pressure (BP), but little or no change in 24 hours blood pressure (ABPM).
The objective of the study was to test the hypothesis that efficacy of medication therapy for hyper
tension is identical in any grading of severity of baseline blood pressure. The authors retrospectively
analysed ABPM data from mild to moderate hypertensive patients. Efficacy in decreasing blood pres
sure by antihypertensives has linear relation to baseline blood pressure. Response to antihypertensive
agents in white-coat hypertension is minimal but a significant effect still persists and the possibility
of hypotensive adverse events from medication in the case cannot be overlooked.
Keywords : Ambulatory Blood Pressure Monitoring, Hypertension, White-Coat Hypertension,
Amlodipine, Mibefradil
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