Insulin-like Growth Factors and Their Binding Proteins
in Children with IDDM
SUTTIPONG WACHARASINDHU, M.R.C.P. (UK)*,
SUMARLEE SRIVUTHANA, M.D.*,
SUPHAB AROONPARKMONGKOL, B.SC. *
Affiliation : *Endocrine Unit, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
AbstractThe structure of insulin-like growth factor (IGF), especially IGF-1, and its receptor is similar
to that of insulin. Therefore, the changes of IGFs and IGF-binding proteins may be related to glucose
homeostasis. in children with insulin dependent diabetes mellitus (IDDM). Sixty-three fasting blood
samples of,21 children with IDDM attending 3 consecutive diabetic clinics were studied. The HbAlc
progressively decreased from the 1'1 to the 3n1 visit. IGF-I levels, both total and free forms, were not
significantly different from that of control. IGFBP-3 levels in 3 visits (3406±305, 3376±252, and
2406±247 ng/mL) were significantly lower than that of control (5020±415ng/mL) with the p value
of 0.007, 0.002, and< 0.001 respectively. IGFBP-1 levels in the 1'1 and 2"d visits (102.1±12.9 and
114.1±14.5 ng/mL) were significantly higher than that of control (60.1±15.2 ng/mL) with the p value
of 0.03 and 0.01 respectively, but not in the 3n1 visit. IGF-I level had a positive correlation with
IGFBP-3 (R=0.56, p=O.Ol) and free IGF-I (R=0.53, p=O.Ol). Free IGF-I had a negative correlation
with IGFBP-1 (R=-0.64, p=O.Ol). IGF-11 at the 1'1 visit had a negative correlation with HbAlc (R=
-0.49, p=0.047). The authors found no correlations between IGF-I, IGFBP-3, free IGF-I, IGFBP-1
and HbAlc in the study. The patients' height SDS followed the genetic height potential. It was,
therefore, postulated that a near normal i(~e IGF-I level in diabetic children resulted from a balance
of interaction between IGFBP-1 and IGFBP-3 to total IGF-I in order to keep the normal ~etabolic
status as much as possible.
Keywords : Insulin-Like Growth Factor-I (IGF-I), Insulin-Like Growth Factor-II (IGF-11), Free IGF
I, IGF-Binding Protein-! (IGFBP-1), IGF-Binding Protein-3 (IGFBP-3), Insulin
Dependent Diabetes Mellitus (IDDM)
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