Vertical Transmission of Dengue Infection in Thai Infants : Two Case Reports

URAIWAN CHOTIGEAT, MD*, SIRIPEN KALA Y ANAROOJ, MD**, ANANDA NISALAK, MD***

Affiliation : * Neonatal Unit, ** Infectious Unit, Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok 10400, ***Department of Virology, Armed Force Research Institute of Medical Sciences, Bangkok 10400, Thailand.

AbstractDengue infection is hyperendemic in tropical countries especially in Thailand. Most dengue infections occur during childhood but some adults may remain susceptible to infection. About 30 per cent of dengue infection are reported in patients> 15 years old. Some pregnant women may also be susceptible to dengue and if they experience dengue infection, they can transmit the dengue viruses to their babies. The authors report two babies who developed mild dengue illness, dengue hemorrhagic fever (DHF) grade II, beginning on their 6'h day of life. Both of them had low grade fever, hepatomegaly and generalized petechial rash. The first baby had Hct ranging from 46 to 40 per cent with minimal right pleural effusion. The lowest platelet count was 19,000 cells/mm3 His mother had dengue shock
•syndrome with masssive post partum bleeding. The second baby had dengue 2 infection while his mother had dengue fever. His Hct had also risen from 52 per cent to 61 per cent with right pleural effusion. His lowest platelet count was 7,000 cells/mm3 Both mothers and their babies had a complete
•recovery although the first baby had prolonged thrombocytopenia for two months.

Keywords : Vertical Transmission, Dengue Infection

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