Childhood Helicobacter pylori Infection, Clinical Presenta tions, Endoscopic, Histologic Features and Results of Treat ment
NIY ADA VITHA Y A8AI, MD*
Affiliation : *Gastroenterology and Nutrition Unit, Queen Sirikit National Institute of Child Health, Bangkok 10400, Thailand.
Objective :To study childhood Helicobacter pylori infection concerning the clinical presen tations, endoscopic, histologic features and results of treatment.
Materials and Methods :A retrospective study conducted at the Gastroenterology and Nutri tion Unit, Queen Sirikit National Institute of Child Health (QSNICH) was done from January 1993 to December 2002. All patients presented with recurrent abdominal pain, upper GI bleeding (non-variceal bleeding) chronic vomiting and dyspeptic symptoms who underwent upper GI endoscopy were included in this study. Positive urease test verified by biopsied specimens from the gastric antrum and body and/ or finding the organisms from the specimens were the criteria for diagnosis of H. pylori infection. Cli nical presentations, endoscopic, histologic features and results of treatment in H. pylori infected cases were described. Result : A total of 144 patients who underwent upper GI endoscopy were included in the study. 22 out of 144 cases proved to be infected by H. pylori. Ages ranged from 2.6 to 14 years (mean age 9 years). The male/female ratio was 1 : 1.2. Vomiting and epigastric pain were the leading symp toms. Endoscopic findings were divided into inflammation in the stomach 12 cases, both stomach and duodenum 6 cases and duodenal ulcer 4 cases. Nodular hyperplasia of gastric antrum was found in 8 out of 22 cases. Histologic evidence of chronic gastritis was present in 12 cases, chronic gastroduo denitis 6 cases and chronic duodenitis in duodenal ulcer cases. Treatment regimen consisted of one H 2 blocker (ranitidine) initially which was changed to omeprazole in 2001 combined with 2 antibiotics (amoxycillin and metronidazole) for 14 days.
Conclusion : This study group represented middle and low income groups from around Bangkok and many parts ofThai1and. The prevalence of H. pylori infection in the present study was 15.3 per cent which reflects that H. pylori infection is a common health problem in Thailand. However, because this was only a descriptive study, the authors cannot specify the association between symp toms, endoscopic findings, histologic features and disease.
Keywords : Helicobacter pylori, Childhood
