D-Xylose Absorption in Non-Chronic Diarrhea AIDS Patients with the Wasting Syndrome
SOMCHAI LUANGJARU, MD*, KAIT RUXRUNGTHAM, MD**, NARUMON WISEDOPAS, MD***, V AROCHA MAHACHAI, MD**
Affiliation : * Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima 30000, ** Department of Medicine, ***Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Objective : To compare the intestinal absorptive capacity, permeability function and duo denal histopathology in human immunodeficiency virus (HIV) patients with or without wasting syn drome who had not suffered from chronic diarrhea.
Method : Adult HIV patients who attended Chulalongkom Hospital were included. The sub jects were classified into wasting and non-wasting groups (group I and group II). 25 g oral D-xylose test, oral phenolsulfonephthalein test and duodenal histopathology were performed.
Results : Of thirty-two HIV patients, aged between 25-50 years enrolled, there were 18 and 14 patients in group I and group II, respectively. In both groups, the baseline data, permeability func tion and histopathology were similar. Intestinal absorptive capacity was statistically different, i.e. 5- hour urine D-xylose was 3.96 ± 2.81 g and 5.95 ± 2.47 gin group I and group II respectively (p < 0.05).
Conclusion : This study demonstrated that D-xylose absorption was decreased in non-diar rheal, wasting HIV infected patients. Abnormal absorptive capacity is a common phenomenon found in HIV patients with wasting syndrome as determined by standard 25 g oral D-xylose test.
Keywords : D-xylose Absorption, Permeability Function, HIV Wasting Syndrome
