Efficacy of Albendazole Against Early and Late Stage of Trichinella spiralis Infection in Mice

PADET SIRIYASATIEN, BSc, MD, DTM&H, PhD*, PAISAL YINGYOURD, BSc*, SURANG NUCHPRA YOON, MD, MPH, PhD*

Affiliation : *Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

AbstractEfficacy of albendazole against early and late stage of Trichinella spiralis infection in mice was determined. To determine the efficacy of albendazole against the early stage (enteral phase) of trichinosis, mice experimentally infected with T. spiralis were treated with albendazole 20 mg/kg at 7 days post infection for 15 days. Larvae were recovered from the infected mice 7 days after the treat ment. The reduction rate of the larvae was 100 per cent. Efficacy of albendazole against the late stage {parenteral phase) of infection was determined at 30 days post infection. Mice were treated with albendazole at 20 mglkg for 30 days. Larvae were recovered from the infected mice 7 days after the treatment. The reduction rate of the larvae was 71 per cent compared to the control group. In con clusion, albendazole was more effective in the early stage of infection than the late stage, the reduction was 100 per cent and 71 per cent with respect to the control group respectively.

Keywords : Trichinella spiralis, Trichinosis, Albendazole

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