Serum N-Terminal Pro-Brain Natriuretic Peptide in
Normal Thai Subjects
WATT ANA LEOWATTANA, MD*, CHIRASAK SIRITHUNY ANONT, MD**,
YOSVI SUKUMALCHANTRA, MD***, SOMSAK CHAISUPAMONKOLLARP, MD***,
SERMKIT W AT ANA W AROON, MD***, BHANU CHIV ATANAPORN, BSc****,
CHARUWAN KANGKAGATE, MS*****, NITHI MAHANONDA, MD**,
KIERTIJAI BHURIPANYO, MD**
Affiliation : * Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700,
** Bangkok Heart Institute,
*** Respiratory Center, Bangkok Hospital,
**** Laboratory Department, Bangkok Hospital, Bangkok 10320,
***** Her Majesty Cardiac Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
AbstractAminoterminal portion of pro-brain natriuretic peptide (NT-proBNP) appears to be useful in
the screening, diagnosis and prognosis of left ventricular dysfunction and congestive heart failure.
The purpose of this study was to determine the values of serum NT-proBNP in normal Thai subjects
compared with subjects from other countries. The design is a cross sectional study. The authors
enrolled 243 consecutive healthy subjects (134 males and 109 females) from the checkup department
of Bangkok Hospital for NT-proBNP measurement. The serum fraction was measured for NT-proBNP
concentration by using Elecsys 2010 (Roche Diagnostics, Switzerland). The concentrations of NT
proBNP in normal Thai subjects were 33.30 ± 35.43 pg/ml. The NT-proBNP levels increased with age
(age~ 50 years= 27.56 ± 28.77 pg/ml and age> 50 years= 47.20 ± 45.18 pg/ml, p < 0.001). Females
usually have higher NT-proBNP than males (females= 40.42 ± 31.59 pg/ml, males= 27.51 ± 37.40
pg/ml, p = 0.0045). This study established the NT-proBNP concentrations in normal Thai subjects,
which were not different from other studies. The authors suggested the normal cut-off values for sub
jects aged ~50 years should be 100 pg/ml and the normal cut-off values for subjects aged > 50 years
should be 200 pg/ml. The NT-proBNP assay could be used as a rule out marker for heart failure in
patients and may trigger further cardiac investigation.
Keywords : Normal Thai Subjects, NT pro-BNP, Age, Sex
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