The Efficacy of Thai Capsaicin in Management of Over
active Bladder and Hypersensitive Bladder
SUCHAI SOONTRAPA, MD*, WIROJ RUKSAKUL, MD*,
BUNJERD NONTHASOOD, MD*, PIMOLVAN TAPPAYUTHPIJARN, MS,Pharm**
Affiliation : * Department of Surgery,
** Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
AbstractThis paper has been generated to provide information on the effectiveness of capsaicin treat
ment among patients with overactive or hypersensitive bladder. The evaluation process required appro
ximately I4 (overactive bladder) and II (hypersensitive bladder and primary detrusor instability) parti
=
cipants who received capsaicin intravesically. The solution consisted of capsaicin (concentration 1
mMIL) diluted in 30 per cent ethanol solution 100 mi. All participants went through at least 1 urodyna
mic test 1 month before and after receiving capsaicin intravesical instillation.
The capsaicin treatment for overactive and hypersensitive bladders was very effective. On
the average, (overactive bladder) participants' voiding needs decreased from I6.5 ± 4.8 times/day to
8.6 ± 2.5 times/day, leakage from 9.7 ± 8.I times/day to 2.4 ± 4.3 times/day, bladder capacity from
I60.I ± I23.3 ml to 236.9 ± I46.l ml, and detrusor contraction from 7l.I ± 29.2 cm!Hp to 57.3 ±
27.2 crn!Hp.
On average, (hypersensitive bladder and primary detrusor instability) participants' voiding
needs decreased from (Day time) 19.45 ± 17.99 times to 12.00 ± 8.91 times/day, (Night timt>) 7.09 ±
6.03 times to 4.09 ± 3.8 times, bladder capacity from I97.40 ± I56.06 ml to 323.45 ± 129.46 ml, and
detrusor contraction from 32.64 ± 22.77 cm!Hp to 36.64 ± I9.22 cm!Hp.
Capsaicin efficiency was rated very high for both overactive and hypersensitive bladder and
primary detrusor instability.
In Thailand, it has been possible to produce capsaicin using local chili supplies, thus the price
of the drug itself is very economical. When considering the efficiency and the inexpensive cost of
capsaicin, this treatment would be another great alternative for overactive and hypersensitive bladder
cure.
Keywords : Capsaicin, Overactive Bladder, Hypersensitive Bladder
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